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The Authors and Their Backgrounds

Jaime A. Merchán and Jorge Prieto.

in Cajal and de Castro's Neurohistological Methods

March 2016; p ublished online April 2016 .

Chapter. Subjects: Neuroscience. 8771 words.

Santiago Ramón y Cajal (1852–1934) is considered the father of modern neuroscience. He dedicated his entire life to the investigation of the nervous system and was a pioneer in the...

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Coloration of the Macroglia, Microglia, and Oligodendroglia

M. A. Merchán, J. DeFelipe and F. de Castro Soubriet.

in Cajal and de Castro's Neurohistological Methods

March 2016; p ublished online April 2016 .

Chapter. Subjects: Neuroscience. 9157 words.

This chapter discusses and describes the main procedures for staining macroglia, microglia, and oligodendroglia.

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Continuation of the Methods for Demonstrating the Morphology of Neurons

M. A. Merchán, J. DeFelipe and F. de Castro Soubriet.

in Cajal and de Castro's Neurohistological Methods

March 2016; p ublished online April 2016 .

Chapter. Subjects: Neuroscience. 5579 words.

In 1885, Ehrlich developed one of the most useful neurological techniques; a procedure based on the use of methylene blue, which reveals neuron morphology, and especially, the terminal...

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Decalcifying Agents

M. A. Merchán, J. DeFelipe and F. de Castro Soubriet.

in Cajal and de Castro's Neurohistological Methods

March 2016; p ublished online April 2016 .

Chapter. Subjects: Neuroscience. 992 words.

Decalcifying agents are acidic substances that combine with lime in bone salts, teeth, chitin, etc., forming water-soluble compounds that easily can be removed. Decalcificants are...

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Diagnosis and investigation

Roger Smith and Paul Wordsworth.

in Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton

March 2016; p ublished online May 2016 .

Chapter. Subjects: Rheumatology; Molecular and Cellular Systems. 21963 words.

This chapter deals with clinical diagnosis and analyses, the use of biochemical and radiological investigations including measurements of bone density. Bone histology is also discussed.

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Ectopic mineralization

Roger Smith and Paul Wordsworth.

in Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton

March 2016; p ublished online May 2016 .

Chapter. Subjects: Rheumatology; Molecular and Cellular Systems. 15785 words.

Ectopic (heterotopic) mineralization has many causes. This chapter deals with calcification in the soft tissues and acquired and inherited extraskeletal ossification. The rare disorder of...

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Ehlers–Danlos syndrome and related disorders

Roger Smith and Paul Wordsworth.

in Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton

March 2016; p ublished online May 2016 .

Chapter. Subjects: Rheumatology; Molecular and Cellular Systems. 10220 words.

Ehlers–Danlos syndrome (EDS) is a group of disorders with soft hyperextensible skin and excessive joint mobility largely due to mutations in the genes for the fibrillin collagens. This...

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Enzyme defects and the skeleton

Roger Smith and Paul Wordsworth.

in Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton

March 2016; p ublished online May 2016 .

Chapter. Subjects: Rheumatology; Molecular and Cellular Systems. 12918 words.

Enzyme gene mutations which have a major effect on the skeleton are homocystinuria, hypophosphatemia, and alkaptonuria. Many other mutations include those of osteoclast acidification...

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Fibrogenesis imperfecta ossium and other disorders of mineralization

Roger Smith and Paul Wordsworth.

in Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton

March 2016; p ublished online May 2016 .

Chapter. Subjects: Rheumatology; Molecular and Cellular Systems. 5044 words.

Fibrogenesis imperfecta ossium is a very rare apparently acquired disorder of collagen, which is non-birefringent and unmineralized. There is extreme bone fragility. The cause is unknown....

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Fibrous dysplasia

Roger Smith and Paul Wordsworth.

in Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton

March 2016; p ublished online May 2016 .

Chapter. Subjects: Rheumatology; Molecular and Cellular Systems. 7716 words.

Fibrous dysplasia is a rare heterogenous disorder resulting from postzygotic activating mutation of the GNAS gene. Its main effect is on the skeleton. According to the distribution of the...

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